Over the past several years, perfusion has become an increasingly attractive process in the biopharmaceutical industry. It is seen as an opportunity to improve overall production efficiency and a natural fit for integration into continuous bioprocessing workflows. With this change in manufacturing trends, there is an increased demand for media formulations tailored for perfusion. However, there are a variety of perfusion processes in use today, and the differences in these processes must be considered when evaluating medium candidates. Here, we will provide a brief description of the most common types of perfusion and data showing how a medium that is specifically designed for perfusion can drive increased performance. We will also outline best practices for screening medium candidates for a perfusion process.

Learning Objectives:

• Learn about the different types of perfusion.
• Learn how an easy-to-use perfusion medium can provide high titers in numerous CHO cells from beginning to the end of the workflow regardless of the type of perfusion platform, all while using less medium.
• Find out how a medium can support high cell densities at low medium exchange rates (as low as 1 VVD), which improves process efficiency.

Speaker Information:

Christopher Brau
Staff Scientist, Thermo Fisher Scientific

Christopher Brau is an R&D Staff Scientist and Engineer at Thermo Fisher Scientific's Grand Island, New York location where he is team lead for perfusion media development and process development. Prior to this, Christopher, who has a background in Chemical Engineering and Biochemistry, was an integral part of the Single-Use Technology R&D team specializing in process optimization and scaling, reactor design, process analytical technologies, control systems, and UI.

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