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Affinity and non-affinity chromatography resins are critical to achieving the high purity and yield needed to produce effective and ample vaccines. Affinity resins developed based on the variable antigen-binding region (VHH) of camelid heavy-chain only antibodies can improve selectivity in vaccine purification protocols. Having a varied suite of non-affinity resins can further improve purity and yield. In this article we discuss how the combination of versatile chromatography resins and quality control assessments can accelerate vaccine manufacturing processes.