Webinar: Advances in immune repertoire sequencing for the study of lymphoid neoplasms
Speaker:
Dr. John DeCoteau
Professor of Pathology & Laboratory Medicine
Medical Director, Advanced Diagnostic Research Laboratory
University of Saskatchewan
In this webinar, Dr. John DeCoteau shares insight on the value of immune repertoire sequencing in hematological oncology research applications including clonality profiling, measurable residual disease (MRD) research, and somatic hypermutation frequency determination. He presents his experience utilizing next-generation sequencing in heme-oncology research including recent data obtained using the Ion Torrent Oncomine BCR Pan-Clonality Assay for clonality detection in a cohort of multiple myeloma samples. This novel assay includes primers targeting multiple B-cell receptor chain rearrangements (IGH, IGK, IGL, KDE/Cint), enabling high positive clonality determination rates. He describes how the workflow and flexible sample batching can enhance laboratory efficiency and provides his perspective on the future of this application in routine use.
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