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Gibco CTS Dynabeads Treg Xpander provides an optimized activation signal for activation and expansion of Regulatory T cells and yields high fold expansion of suppressive Tregs with a stable Treg phenotype, which is essential for use of Tregs in clinical applications.
Key features
- Scalable technology for robust activation and expansion of Regulatory T cells
- Clinically relevant numbers of Regulatory T cells with >800-fold expansion after two stimulations
- Aseptically manufactured and ready for clinical trials and commercial manufacturing
- Maintained Treg phenotype (FoxP3) and suppressive function
- Drug Master file available
- Conformity with cGMP guidelines
High Fold Expansion
Figure 1. Optimized activation signal expands Tregs to clinically relevant numbers.
Flow sorted regulatory T cells were expanded with CTS Dynabeads Treg Xpander, CTS DynabeadsCD3/CD28 or competitor technology for 14 days with restimulation at day 9.
Figure 1. Optimized activation signal expands Tregs to clinically relevant numbers.
Flow sorted regulatory T cells were expanded with CTS Dynabeads Treg Xpander, CTS DynabeadsCD3/CD28 or competitor technology for 14 days with restimulation at day 9.
High suppressive potential
Figure 2. Optimized activation signal expands Tregs with high suppressive potential.
Magnetically isolated regulatory T Cells were expanded three times with CTS Dynabeads Treg Xpander for 14 days. Expanded Tregs are highly suppressive.
Figure 2. Optimized activation signal expands Tregs with high suppressive potential.
Magnetically isolated regulatory T Cells were expanded three times with CTS Dynabeads Treg Xpander for 14 days. Expanded Tregs are highly suppressive.