b'Oncology applications CytoScan HD Suite for hematologicMicroarray analysis is a powerful genomic tool that can providemalignancies researchcritical genome-wide information to help guide investigationCapture chromosomal abnormalities and genomic instability, of potential future cancer treatments. Unlike constitutionalwhich are some of the most important aberrations in tumors. applications of microarray analysis, which are performed onThe CytoScan HD Suite assay is designed with 2.67 million whole blood samples, microarray analysis of solid tumors ismarkers for copy number analysis, facilitating comprehensive challenging because tumor tissues are typically formalin fixedcoverage at the exceptional resolution so you do not miss and paraffin embedded (FFPE). important aberrations.OncoScan assays for solid tumors researchDetect deletions, duplications, LOH, cnLOH, breakpoint determination, ploidy, mosaicism, and unbalanced translocations with Applied Biosystems OncoScan CNV assay and Applied Biosystems OncoScan CNV Plus Assay (previously known as Applied Biosystems OncoScan FFPE Assay). OncoScan assays are whole-genome copy number assays designed to detect structural variants that are not well characterized by short-read sequencing or targeted sequencing.Figure 3. Solid tumors refer to a solid mass of cancer cells thatKey featuresgrow in organ systems and can occur anywhere in the body, for example breast cancer (left). Liquid tumors occur in the blood,Exceptional flexibilitydetect chromosomal arm bone marrow or lymph nodes and include types of leukemia,aberrations, gains, losses, focal changes, LOH, and lymphoma and myeloma (right). cnLOH in a single assay, helping to reduce costs and processing times Comprehensive coveragewhole-genome analysis of genes with established significance in cancer and tumor progression as well as those with emerging evidenceCytoScan HD arrayRobust performanceobtain consistent results from lot to analysis allows detectionlot and operator to operatorBroad somatic mutation panelcovering 64 mutations in of copy number variations9 genes (BRAF, EGFR, IDH1, IDH2, KRAS, NRAS, PIK3CA, PTEN, and TP53)and regions of copy-neutralLow sample input and fast resultsget results in 72 loss of heterozygosityhours from only 80 ng of FFPE-derived DNARapid analysisincluded software provides intuitive data across the genome duringvisualization for hundreds of samples in minutesOncoScan CNV Plus Assay offers a high-resolution clinical research work-up ofcopy number detection in priority cancer genesaccurate identification of very small (50125 kb) to hematologic neoplasms. large (Mb) CNVs Madina Sukhanova, PhD,Learn how Dr. Madina FACMG, Assistant ProfessorSukhanova used of Pathology, NorthwesternCMA combined with NGS assays to University, Feinberg School identify and research of Medicine genetic aberrations associated with specific prognoses in different types of cancer. 8 Watch the webinar'