b'Ion ReproSeq PGS kits PGD-SEQ kitsVersatile and comprehensivedetect whole-chromosome,PGD-SEQ kits offer over 200 gene panels to research mosaic, and small CNVs, from just 6 pg of DNA from a singleembryo status of common and rare monogenic/single-gene cell or multiple cells disorders (PGT-M) for IVF. Targets of interest are identified Scalable throughputthree kit configurations enablethrough carrier screening research and/or known family history.analysis of up to 16, 24, or 96 samples in a single run on aComplete kit reagents for PGT-M library preparation to single platform analyze up to 15 samplesRapid, end-to-end NGS workflowcells to results in lessComprehensive familial carrier status using proprietary than 10 hours* and minimized user error, with 2 hours*linkage analysis softwarehands-on time Compatible with the Ion ReproSeq PGS Kit for combined Enhanced interpretation of results with Ion ReporterPGT-M and PGT-A analysis from a single research sampleSoftwaremosaicism detection, gender masking, and easy-to-interpret data plotsView our growing list of over 200 PGD-SEQ panels.Custom panels available upon request. Combined PGT-A and PGT-M workow using Ion Torrent targeted NGSSample input Prepare library Prepare template Run sequence Analyze dataIVF research sample andPGT-A: Whole-genomePGT-A and PGT-MSequence PGT-A and Ion Reporter Software informative DNA sampleamplication (WGA) andlibraries pooled forPGT-M samples with an for aneuploidy calling to from family members fragment libraryisothermal amplicationIon 500 series chip on the obtain PGT-A reportconstruction with thewith the Ion ChefIon GeneStudio S5Ion ReproSeq PGS kit Instrument Series System PGD-SEQ Software for linkage analysis to PGT-M: Target amplication obtain PGT-M reportand library preparation from WGA material withthe PGD-SEQ kit* Turnaround time for the Ion ReproSeq PGS Kit with Ion 510 Chips (16 samples/run) is less than 10 hours with less than 2 hours of hands-on time.Ion Reporter SoftwareThe aneuploidy analysis workflow in Ion Reporter Software makes analyzing and reporting aneuploidy results simple and fast. This low-pass coverage analysis workflow processesContact a reproductive health specialistsamples by comparing them to a built-in bioinformatics control baseline to deliver the ploidy status of each chromosome in a sample. Users can visualize aneuploidy profiles using the customized Integrative Genomics Viewer (IGV) karyotype view and create their own interpretive report.Detection of aneuploidies, segmental aneuploidies, and mosaicism using Ion ReproSeq kitsthermofisher.com/pgt 7'