b'Download the Copy number statewhitepaper Weighted Log2 ratioCytoScan HD Suite: Allele differencea comprehensive solution for analyzing karyotypes inSmooth signalhematological malignanciesFigure 4. Watch now Log2ratio Chromothripsis detected on chromosome 18 using Allele difference CytoScan HD (top) Webinar: Exploring theand on chromosome genetic landscape of solidB allele frequency 19 using OncoScan (bottom), revealed by tumors using whole-genomethe sequential copy copy number analysisnumber changes and the multiple breakpoints seen in the different tracks.Table 2. Suite specification for oncological clinical research sample profiling solutionsOncoScan CNV Assay CytoScan HD Suite OncoScan CNV Plus Assay*Research application High resolution analysis of genome wide CNVs inHigh resolution analysis, up to 50 kb in top liquid and solid tumors cancer genes and 300 kb across whole genome in FFPE and fresh frozen tissuesSample types Blood, bone marrow, and fresh and frozen tissue FFPE, fresh and frozen tissueSize of aberration**Gains: 50 kb Gains: 50 kb(analytical claims) Losses: 25 kb Losses: 50 kbLOH/AOH: 3 Mb LOH/AOH: 10 MbMosaicism (% aberrant cells): approximately 15%Mosaicism (% aberrant cells): 15% Input DNA 10-250 ng80 ngProbe structure 2.67 million markers for whole genome coverage 220,000 molecular inversion probes (MIPs), whole 1.95 million nonpolymorphic markers genome coverage~743,000 SNP probes for LOH/AOH analysis, and5,700 non-polymorphic probessample tracking 216,000 SNP probesProtocol 34 days 23 daysClick on each icon to downloadproduct literature*OncoScan CNV Plus Assay includes somatic mutation panel covering 64 mutations in 9 genes (BRAF, EGFR, IDH1 and 2, KRAS, NRAS, PIK3CA, PTEN, and TP53)**Size of aberrationThe size of the segment call depends on the average marker spacing in the region. Best performance can be achieved in regions with higher marker coverage. Mosaicism detection may depend on the size of the altered segment and the type of aberration involved. Mosaicism in cancer is classified by % aberrant cells in the sample and is called in ChAS software.250 ng is optimal but users have reported success using as little as 10 ng starting DNA.9'